A study of the factors influencing the quality of life and social support of people suffering with mental disabilities, who use mental health centers. The purpose of the study includes the general characteristics of subjects, characteristics of the mental health center, the mean score of social support and quality of life of people living with mental disabilities. The 132 questionnaires were administered by meeting directly with subjects and personal visits. 112 Questionnaires were returned(85% response rate). Data was collected from mentally disabled patients in Chungnam Mental Health Center. difference in quality of life by using t-test, one way ANOVA table, the relationship between social support, quality of life by pearson correlation coefficients, and relevant factors affecting quality of life by multiple regression with the SPSS 19.0 program. This study revealed that the group that participated regularly in the day time rehabilitation program showed better social support and positive attitude to a better quality of life than the other group that participated irregularly. This result is directly proportional to the participation frequency to the program during the recent 3-month duration. Another correlation with religion was found in the study due to the fact that a buddhist group showed positive significance in quality of life than non-religious groups. The results show positive correlation between the improvement of the quality of life of patients living with mental disabilities and the social support they receive.