The purpose of this study was to identify the influencing factors of college adjustment in nursing students. A quantitative descriptive design was used to study 400 nursing students in Busan and Ulsan, recruited from May 1 to 30, 2011. The instruments used were the clinical stress scale, stress coping scale and college adjustment problem checklist. The data were analysed SPSS program, using descriptive statistics, Pearson correlation coefficient, and simultaneous multiple regression. Findings of the study can be summarized as follows; First, the average of clinical stress was 3.68 points, the problem-solving coping was 2.85 points, the emotional-focused coping was 2.48 points, and college adjustment was 3.03 points. Second, The correlation of the clinical stress and college adjustment relations showed negative correlation in all areas. The correlation of problem-solving and emotional-focused coping and college adjustment showed positive correlation. Third, The significant predictors of college adjustment were satisfaction in major, psychological factors, problem-solving coping, perceived health status, emotional-focused coping, knowledge, skills, assignment/reports. These variables showed explanatory power of 43.2%. The study suggested to help reduce clinical stress and to strengthen problem-solving coping for college adjustment in nursing students.