A large aspheric mirror is a key component for large astronomical telescopes and high resolution satellite cameras. Since it is large and has an aspheric form, it is much more difficult to fabricate it compared to the similar size of spherical mirror. Especially, the opto-mechanical design and analysis is critical to reduce the deformation of mirror surface due to the external forces such as gravity or temperature change, as the mirror size is larger and lightweighting ratio is increased. The design requirements for the mirror are different depending on the particular ground and space applications because the environmental conditions are changed. In this paper, we explain the opto-mechanical design and analysis for ground and space applications that are among the most difficult to achieve among several technologies related to development of the large aspheric mirror.