A novel hybrid active power filter (NHAPF) that can be adopted in high-voltage systems is proposed in this paper. The topological structure and filtering principle of the compensating system is provided and analyzed, respectively. Different controlling strategies are also presented to select the suitable strategy for the compensation system. Based on the selected strategy, the harmonic suppression function is used to analyze the influence of system parameters on the compensating system with MATLAB. Moreover, parameters in the injection branch are designed and analyzed. The performance of the proposed NHAPF in harmonic suppression and reactive power compensation is simulated with PSim. Thereafter, the overall control method is proposed. Simulation analysis and real experiments show that the proposed NHAPF exhibits good harmonic suppression and reactive power compensation. The proposed compensated system is based on the three-phase four-switch inverter, which is inexpensive, and the control method is verified for validity and effectiveness.