When users use medical volume rendering applications, selecting specific region of volume data and observing the region by magnification is a common process.As the wood-grain artifact is arise from the magnified image, the jittered sampling technique has been used to remove the problem. However, the jittered sampling leads to some noise along the volume edge. In this research, we reveal the reason of the noise, and present a solution. To remove the wood-grain artifact without the noise, we propose the empty space jittering and the sampling alignment method. Using these methods, we can produce high quality volume rendering images without noticeable time consuming.