Novel breakthrough random-hole optical fibers (RHOFs) are fabricated in a draw tower facility, by tapering an optical fiber preform packed with a silica powder mixture capable of producing air holes in situ at the high temperature of tens of hundreds in degrees Celsius. Structural and propagation characteristics of the porous RHOF are explained briefly. Experimental investigations of the invented RHOF are performed for pressure sensor applications. Remarkable results are obtained for the RHOF with desirable pressure sensitivity independent of temperature, as is required for harsh conditions as in oil reservoirs.