Purpose: The purpose of this study was to identify factors contributing to health-related quality of life in patients under rehabilitation after stroke. Methods: A descriptive correlational study design was used. Ninety-two stroke patients under rehabilitation from a university hospital were included. Data were collected on March and April, 2013 using structured questionnaires. Hierarchial multiple regression analysis was used to identify factors influencing health-related quality of life. Results: There were significant differences in health-related quality of life according to type of impairment. The health-related quality of life had significant correlations with age, functional dependency, and stress. Factors influencing health-related quality of life for stroke patients under rehabilitation were stress, functional dependency, type of impairment, and age, which explained about 34.5% of total variance. Conclusion: To promote health-related quality of life for stroke patients under rehabilitation, stress and functional dependency should be managed in this population, especially for older adults. Also these results can be utilized in the development of program for helping rehabilitation of stroke patients. The effect of depression and anxiety on health-related quality of life should also be addressed in future research.