The purpose of this study was to test the multiple mediating effects between attachment and life quality among university freshmen, regards on positive and negative affect, stress, social support and mental health as mediating factors. 200 freshmen were selected for the questionnaire study in a university in Busan. There were significant correlations among positive and negative affect, stress, social support, mental health and life quality with attachment. The maximum likelihood estimation revealed that attachment had no direct link with life quality. Attachment had indirect effects on life quality, mediated by positive affect and mental health. The results and limitations of this study were also discussed, from the perspective of attachment theory and previous studies.