In this study, we propose the method of optimally selecting material of front pillar (A-pillar) and package tray for minimizing weight while satisfying vehicle requirements on static stiffness and dynamic stiffness. First, we formulate a material selection optimization problem. Next, we establish the CAE procedure of evaluating static stiffness and dynamic stiffness. Then, to enhance the efficiency of design work, we integrate and automate the established CAE procedure using a commercial process integration and design optimization (PIDO) tool, PIAnO. For effective optimization, we adopt the approach of metamodel based approximate optimization. As a sampling method, an orthogonal array (OA) is used for selecting sampling points. The response values are evaluated at the sampling points and then these response values are used to generate a metamodel of each response using the radial basis function regression (RBFr). Using the RBFr models, optimization is carried out an evolutionary algorithm that can handle discrete design variables. Material optimization result reveals that the weight is reduced by 49.8% while satisfying all the design constraints.