This paper shows how the performance of an ESC(Electronic Stability Control) system can be affected by the selection of in-vehicle network protocols such as CAN or FlexRay. The vehicle control performance under ESC operation is analyzed by EILS(ECU-In-the-Loop Simulation). The experimental set-up for the EILS of the ESC system consists of two 32-bit microcontroller boards communicated with CAN or FlexRay protocols. A 7-DOF vehicle model and an ESC algorithm with 2-DOF reference vehicle model are implemented on each microcontroller respectively. It is shown by experimental results that the ESC system using the FlexRay protocol can achieve better performance than that using the CAN protocol for a fast and accurate lane changing.