This paper presents the comparison of heat transfer and pressure drop of various secondary refrigerants (single-phase and two-phase) in the indirect refrigeration system. The main results were summarized as follows: In case of heat transfer, it is useful to use secondary refrigerants in low evaporating temperature region and the heat transfer coefficient of single-phase is larger than two-phase secondary refrigerants. In case of pressure drop, it is useful to use secondary refrigerants in high evaporating temperature region and the pressure drop of two-phase is smaller than single-phase secondary refrigerant. Also, $CO_2$ is the best useful because pressure drop of $CO_2$ among the secondary refrigerants is the smallest.