The This is a study on the level of depression and parental efficacy of the mothers who have children with disabilities. Thus, it compared the level of depression of the mothers of children with intellectual disabilities and the mothers of children with cerebral palsy. Both groups displayed mild depressive state; however, there was not a statistically significant difference between the two groups. Although there was not a significant difference between the two groups for parent efficacy, the factors of the number of family members and whether to participate in self-help meetings displayed a significant difference in the relationship of parent efficacy in accordance with the demographic characteristics. Of the mothers of children with intellectual disabilities, those mothers who were participating in the self-help meetings were found to have a higher parent efficacy than the mothers who were not participating in the self-help meetings. However, of the mothers of children with cerebral palsy, those mothers who were not participating in the self-help meetings were found to have a higher parent efficacy. As for the correlation between level of depression and parent efficacy, it was found that the higher the parent efficacy was, the lower the level of depression was. The interest was found to be higher with higher parent efficacy when sub-dividing and comparing frustration and interest that were the sub-domains of parent efficacy.