With the recent changes in the environment of weapon systems acquisition, the systems development is becoming more susceptible to a variety of risks. To cope with this situation, US DoD has been emphasizing the importance of constantly applying the test and evaluation (T&E) process throughout the whole life cycle of the weapon systems. In particular, the safety requirements are called for attention while dealing with system risks. To this end, the present paper is aimed at studying the T&E process which incorporates the systems safety in weapon systems development. Analyzing and modeling the relevant processes has made it possible to achieve the objective. As a case study, the model results were applied to the development of unmanned aerial vehicles.