This paper investigates application of a control algorithm called model predictive sliding mode control (MPSMC) to active vibration suppression of a cantilevered aluminum beam. MPSMC is a relatively new control algorithm where model predictive control is employed to enhance sliding mode control by enforcing the system to reach the sliding surface in an optimal manner. In previous studies, it was shown that MPSMC can be applied to reduce hysteretic effects of piezoelectric actuators in dynamic displacement tracking applications. In the current study, a cantilevered beam with unknown mass distribution is selected as an experimental test bed in order to verify the robustness of MPSMC in active vibration control applications. Experimental results show that MPSMC can reduce vibration of an aluminum cantilevered beam at least by 29% regardless of modified mass distribution.