In this study, the effect of presence and distribution of masonry infill walls on the mid-rise steel frame structures having soft ground storey was evaluated by implementing finite element (FE) methods. Masonry infill walls were distributed randomly in the upper storey keeping the ground storey open without any infill walls, thus generating the worst case scenario for seismic events. It was observed from the analysis that there was an increase in the seismic design forces, moments and base shear in presence of randomly distributed masonry infill walls which underlines that these design values need to be amplified when designing a mid-rise soft ground storey steel frame with randomly distributed masonry infill. In addition, it was found that the overstrength related force modification factor increased and the ductility related force modification factor decreased with the increase in the amount of masonry infilled bays and panels. These must be accounted for in the design of mid-rise steel frames. Based on the FE analysis results on two mid-rise steel frames, design equations were proposed for determining the over strength and the ductility related force modification factors. However, it was recommended that these equations to be generalized for other steel frame structure systems based on an extensive analysis.