The seismic response of RC space frame structures with isolated footing resting on a shallow soil stratum on rock is presented in this paper. Homogeneous soil stratum of different stiffness in the very soft to stiff range is considered. Soil, footing and super structure are considered to be the parts of an integral system. A finite element model of the integrated system is developed and subjected to scaled acceleration time histories recorded during two different real earthquakes. Dynamic analysis is performed using mode superposition method of transient analysis. A parametric study is conducted to investigate the effect of flexibility of soil in the dynamic behaviour of low-rise building frames. The time histories and Fourier spectra of roof displacement, base shear and structural response quantities of the space frame on compliant base are presented and compared with the fixed base condition. Results indicate that the incorporation of soil flexibility is required for the realistic estimate of structural seismic response especially for single storey structures resting on very soft soil.