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서지반출
백서 좌골신경의 압박손상에 대한 단기간 스테로이드 투여 시 복합근활동전위의 변화
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  • 백서 좌골신경의 압박손상에 대한 단기간 스테로이드 투여 시 복합근활동전위의 변화
저자명
김소현,박광원,백준석,정태영,김미리,박상준,Kim. So-Hyun,Park. Kwang-Won,Baek. Joon-Seok,Jung. Tae-Young,Kim. Mee-Lee,Park. Sang-Jun
간행물명
대한악안면성형재건외과학회지
권/호정보
2013년|35권 1호|pp.25-30 (6 pages)
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대한악안면성형재건외과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Purpose: Many surgical procedures in oral and maxillofacial area can induce trauma to the peripheral nerve. The aim of the study is to evaluate the effects of short-term steroid therapy on nerve recovery after crush injury. Methods: Sixteen rats were randomly divided into two groups. The right sciatic nerves were exposed, crushed, and sutured. The control group was not given steroids. The test group was injected with dexamethasone disodium phosphate (2 mg/kg body weight/day) for 7 days. In all animals, compound muscle action potential (CMAP) was recorded before and at 1, 7, 14, 21, and 28 days after injury. Results: The amplitude of the CMAP before and at 1, 7, 14, 21, and 28 days after injury were $53.20{pm}4.80$ mV, $20.12{pm}5.38$ mV, $30.01{pm}14.15$ mV, $31.14{pm}13.56$ mV, $31.73{pm}16.33$ mV, and $37.23{pm}16.98$ mV in the control group, and $55.25{pm}6.72$ mV, $18.62{pm}6.26$ mV, $29.50{pm}13.06$ mV, $32.90{pm}13.226$ mV, $30.17{pm}11.80$ mV, and $38.41{pm}12.27$ mV in the test group, respectively. The nerve conduction velocity was $18.82{pm}3.94$ m/s, $16.73{pm}3.48$ m/s, $19.60{pm}2.45$ m/s, $18.68{pm}3.94$ m/s, $18.02{pm}3.51$ m/s, and $19.25{pm}3.88$ m/s in the control group, and $18.94{pm}3.48$ m/s, $17.28{pm}2.53$ m/s, $7.57{pm}2.54$ m/s, $18.77{pm}2.12$ m/s, $19.48{pm}1.55$ m/s, and $19.22{pm}2.97$ m/s in the test group, respectively. There was no significant difference between both groups (P>0.05). Conclusion: This study did not show any therapeutic effect of short-term administration of steroids on injured rat sciatic nerve. Further studies are needed.