Cold-formed profiles have been largely used in the building industry because they can be easily produced and because they allow for a wide range of sections and thus can be utilized to meet different project requirements. Attainment of maximum performance by structural elements with low use of material is a challenge for engineering projects. This paper presents a numerical study aimed at minimizing the weight of lipped and unlipped cold-formed channel columns, following the AISI 2007 specification. Flexural, torsional and torsional-flexural buckling of columns was considered as constraints. The simulated annealing method was used for optimization. Several numerical simulations are presented and discussed to validate the proposal, in addition to an experimental example that qualifies its implementation. The ratios between lips, web width, and flange width are analyzed. Finally, it may be concluded that the optimization process yields excellent results in terms of cross-sectional area reduction.