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Synthesis and evaluation of octenyl succinate anhydride derivative of fenugreek gum as extended release polymer
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  • Synthesis and evaluation of octenyl succinate anhydride derivative of fenugreek gum as extended release polymer
  • Synthesis and evaluation of octenyl succinate anhydride derivative of fenugreek gum as extended release polymer
저자명
Sav. Ajay Kumar,Fule. Ritesh Amol,Ali. Meer Tarique,Amin. Purnima
간행물명
Journal of pharmaceutical investigation
권/호정보
2013년|43권 5호|pp.417-429 (13 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In current study, fenugreek gum (FG) plant derived product was investigated as a release retarding polymer. The octenyl succincate anhydride derivative of fenugreek gum (OSFG) was synthesized to introduce hydrophobic property and investigated for its drug release retarding property with reference to FG. The reaction was carried out in anhydrous conditions at different temperature ($40-98^{circ}C$) using $NaHCO_3$ as a mild base catalyst and the influences of three factors such as reagentstrate concentration, reaction temperature and time on the degree of substitution of OSFG were studied. Highly water-soluble metoprolol succinate (MPS) and poorly water-soluble carbamazepine (CBZ) were selected as model drug as for release studies. It was observed that increase in reaction temperature and reagent concentration resulted in high degree of substitution with significant decrease in viscosity. Reaction carried out at $98^{circ}C$< for 2 h showed high degree of substitution (0.133) with moderate retention of viscosity compared to plain FG. FTIR, DSC, XRD, solid state CPMAS 13C-NMR, and SEM studies provide structural information of synthesized OSFG. MPS ER tablet prepared with drug:OSFG:FG at the weight of 1:4:2 and CBZ ER tablet with drug:OSFG at the weight ratio of 1:3, respectively. Both formulations showed similar drug release profile compared to marketed formulations. Optimized tablet formulations were found to be stable under stability condition according to ICH guidelines. It was concluded that the developed formulations with OSFG have a release retarding property and can be used alone or in combination with other polymers for a controlled release.