When collapse occurs due to explosion near a tunnel, fragmentation zone should be comprehended quickly to recover the function of the tunnel itself. In this study, a method to interpret explosion behavior and predict the fragmentation zone fast. For this purpose, the various 3D-meshes were generated using SolidWorks and explosion analyses were carried out using AUTODYN. The influence of explosion variables such as source location on fragmentation volume were examined by performing sensitivity analyses. Also, a training database for an artificial neural network analysis had been established and the optimal training model was selected, and the predicted results for fragmentation volume and radius were verified. The suggested method had demonstrated that it could be effective for the fast prediction of fragmentation zone.