Purpose: This study was done to explore the level of life stress, depression, and suicidal ideation and to identify the associated factors of suicidal ideation (SI) among college nursing students. Method: The design of this study was a descriptive survey design using a convenience sampling. Data collection was done using self-questionnaire from 124 students in 2 universities located in Gyeonggi and Chungnam provinces. The collected data were analyzed using descriptive statistics, ANOVA, t-test, Pearson correlation coefficients, and hierarchical multiple regression. Results: Study participants reported low level of SI, depression, and life stress ($44.45{pm}19.21$, $8.40{pm}5.94$, $40.65{pm}32.17$). The 53% of variance in SI was significantly explained by life stress related value (${eta}=.41$, p<.001), life stress related to interpersonal relationship with family (${eta}=.19$, p=.014), life stress related to interpersonal relationship with friends (${eta}=.34$, p<.001), and depression (${eta}=.36$, p<.001). Conclusions: The results indicate that to decrease the SI in these students, an active interest in the students is needed to lower stress levels in interpersonal relationships with family and friends, in life stress related to value, and for relief of depression. Suicide prevention programs specific to the level of life stress and depression need to be developed for nursing students.