Antibiotic is one of the mainly prescribed drugs in dental office. The substantial part of all antibiotics used in dental office is given to patients without signs or symptoms of infection to prevent infections, and antibiotics became the most widely abused prescribed drugs on the basis of inappropriate indications, dosages and durations. Considering that antibiotics are one of the drugs that affect not only a single patient but also entire populations of individuals through their collective effects on microbial ecology, the importance of proper use of antimicrobial therapy can hardly be overemphasized. Therefore, the main considerations for antibiotic therapy in denial office were summarized here.