Purpose: The purpose of this study was to examine the influence of alcohol outcome expectancy, depression and suicidal ideation on problematic drinking among college students. Methods: This study was conducted using a descriptive survey design. Participants were 205 college students from two universities in Jeollanamdo. Data were collected from March 10 to March 25 in 2014 using self-report questionnaires. Data were analyzed by t-test, ANOVA, Pearson correlation coefficient and multiple regression using SPSS 19.0. Results: Of the participants, 57.6% were in problem drinking group. There were significant positive correlations between alcohol outcome expectancy, depression and problematic drinking of college students. However, suicidal ideation was not correlated with problematic drinking. It was also found that alcohol outcome expectancy, low academic performance and depression influence on problem drinking of college students. These variables did not influence on suicidal ideation. Conclusion: Based on the findings, problem drinking prevention programs should be developed to decrease alcohol outcome expectancy and regulate negative emotions such as depression, in order to prevent problematic drinking among college students.