The need for assessing dynamic response of typical industrial piping systems subjected to seismic loading motivated the authors to apply model reduction techniques to experimental dynamic substructuring. Initially, a better insight into the dynamic response of the emulated system was provided by means of the principal component analysis. The clear understanding of reduction basis requirements paved the way for the implementation of a number of model reduction techniques aimed at extending the applicability range of the hybrid testing technique beyond its traditional scope. Therefore, several hybrid simulations were performed on a typical full-scale industrial piping system endowed with a number of critical components, like elbows, Tee joints and bolted flange joints, ranging from operational to collapse limit states. Then, the favourable performance of the L-Stable Real-Time compatible time integrator and an effective delay compensation method were also checked throughout the testing campaign. Finally, several aspects of the piping performance were commented and conclusions drawn.