LED lamp arrangement is a critical issue in indoor visible light communication (VLC) system. In this paper, we analyze the illumination distribution under the arrangement of $2{ imes}3$ and propose a method to find the optimal lamp arrangement. The method, based on the MIMO (Multiple Input/Multiple Output) system model and taking the first order reflection into consideration, enables accurate analysis of the arrangement of the LED lamps for any room. The studies show that under the optimal arrangement the uniformity of illumination is improved from 0.55 to 0.86, which guarantees that users can get almost equal lighting effects, no matter where they locate themselves. At the same time, the RMS delay spread distribution which is used to evaluate the inter-signal-interference (ISI) is analyzed, and the simulation results indicate that the optimal arrangement also can improve the communication quality by reducing the fluctuation of the RMS delay spread.