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항균성 Ag-30CaO·70SiO2 Gel의 MC3T3 세포적합성에 관한 연구
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  • 항균성 Ag-30CaO·70SiO2 Gel의 MC3T3 세포적합성에 관한 연구
저자명
윤금재,류재경,안응모,김윤종,김택남,노인섭,조성백,Yoon. Geum-Jae,Ryu. Jae-Kyung,An. Eung-Mo,Kim. Yun-Jong,Kim. Taik-Nam,Noh. In-Sup,Cho. Sung-Beck
간행물명
한국재료학회지
권/호정보
2014년|24권 12호|pp.671-676 (6 pages)
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한국재료학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

It is known that bones get damaged by accidents and aging. Since the discovery of Bioglass, various kinds of ceramics have been also found to bond to living bone; some of these ceramics are already being clinically used as bone-repairing materials. In the present study, antibacterial calcium silicate gel ($Ag-30CaO{cdot}70SiO_2$ gel) was prepared by sol-gel method in order to control the microstructure, which is related to the dissolution rate and induction period of apatite formation in body environment. In addition, biological $Ag-30CaO{cdot}70SiO_2$ is tested. This was done to impart antimicrobial activity to the $30CaO{cdot}70SiO_2$. Ag ion was added during sol-gel synthesis to replace the $H_2O$ added during the making of the $30CaO{cdot}70SiO_2$ gel, which has silver solutions of various concentration. After the sol-gel process, 1N-$HNO_3$ solution was used to wash the gel when synthesizing the gel, in order to maintain the porous structure and remove PEG, water soluble polymers. Then, the apatite forming ability of the sol-gel derived CaO-$SiO_2$ gels was investigated using simulated body fluid (SBF), which had almost the same ion concentration as that of human blood plasma. The gels were analyzed by FT-IR spectroscopy, SEM observation, XRD, and fluorescent microscopy. The apatite was successfully created even after washing the gel; apatite is present in an amorphous state, and was found to affect the concentration of the Ag ion in cells in MC3T3 live & dead assay results. From these results, it is suggested that a good material that can be used to repair defects of nature bone is $Ag-30CaO{cdot}70SiO_2$ gel.