The structural design of the ships includes two main issues which should be checked carefully, namely the extreme structural response (yielding & buckling) and the fatigue structural response. Even if the corresponding failure modes are fundamentally different, the overall methodologies for their evaluation have many common points. Both issues require application of two main steps: deterministic calculations of hydro-structure interactions for given operating conditions on one side and the statistical post-processing in order to take into account the lifetime operational profile, on the other side. In the case of ultra large ships such as the container ships and in addition to the classical quasi-static type of structural responses the hydroelastic structural response becomes important. This is due to several reasons among which the following are the most important: the increase of the flexibility due to their large dimensions (Lpp close to 400 m) which leads to the lower structural natural frequencies, very large operational speed (> 20 knots) and large bow flare (increased slamming loads). The correct modeling of the hydroelastic ship structural response, and its inclusion into the overall design procedure, is significantly more complex than the evaluation of the quasi static structural response. The present paper gives an overview of the different tools and methods which are used in nowadays practice.