Purpose: The purpose of this study was to examine the levels of resilience, depression, and self-esteem of hemodialysis(HD) patients, and to find out the factors influencing resilience. Methods: The subjects of this descriptive correlational study was 83 outpatients in H hospital in Seoul, Korea, who receive hemodialysis regularly. Data was analyzed by SPSS/WIN 18.0 program. Results: The resilience of HD patients were statistically different by gender, job, economical state, most supportive person, and recent condition. Self-esteem had positive correlation, while depression had moderate negative correlation with the resilience of HD patients. In regression analysis, depression had significant explanation power, which accounted for 25.4% of the resilience. Conclusion: The results of this study provide basic data for developing a resilience promoting program. Since health-related conditions of HD patients affect their levels of resilience, individualized assessment and management of complications are necessary. Also, as the resilience is related to family support, activating support groups for HD patients and their spouses would be helpful to promote their resilience.