A reliability evaluation or prediction can be defined as MTBF which stands for mean time between failures (Exclusively for repairable failures). Spindle system has huge effect on performance of machine tools and working quality as well as is required of high reliability. Especially, it takes great importance in producing automobiles which includes a large number of working processes. However, it is unusually difficult to predict reliability because there are lack of data and research about reliability of spindle system. Standards and methods of examinations for reliability evaluation of machine tools are scarce at local and abroad as well. Therefore, this research is meant to improve the reliability of spindle system before mass produced with developing standards of reliability and methods of examinations through FMEA to assess reliability of spindle system in prototype stages of developing high speed spindle system of machining center.