The safety relating to leakage of water and pitch instability of ship chambers of the full balanced hoist vertical shiplifts has been the focus of adoption of the type of vertical shiplifts. This paper aims to remove the doubts through theoretical and engineering researches. The leakage and pitch stability of ship chambers of full balanced hoist vertical ship lifts are investigated on the basis of theoretical analysis and exploration of engineering measures. Regarding the issue of leakage of ship chambers, a mathematical model on leaking process is built and corresponding formula and coping measures are obtained which can be applied in control program of ship lifts by linking with monitoring. The concept of safety grade is put forward to seek the best technical and economic index and the corresponding technical measures are for different grades of ship lift is suggested. For the issue of pitch instability, a methodology of combining theoretical deduction and summary of achievements of design and operation of the type of the full balanced hoist shiplifts is adopted, and the formula for design about pitch stability of ship chambers is derived.