For a building with a dominant windward wall opening, the wind-induced internal pressure response can be described by a second-order non-linear differential equation. However, there are two ill-defined parameters in the governing equation: the inertial coefficient $C_I$ and the loss coefficient $C_L$. Lack of knowledge of these two parameters restricts the practical use of the governing equation. This study was primarily focused on finding an accurate reference value for $C_I$, and the paper presents a systematic investigation of the factors influencing the inertial coefficient for a wind-tunnel model building including: opening configuration and location, wind speed and direction, approaching flow turbulence, the model material, and the installation method. A numerical model was used to simulate the volume deformation under internal pressure, and to predict the bulk modulus of an experimental model. In considering the structural flexibility, an alternative approach was proposed to ensure accurate internal volume distortions, so that similarity of internal pressure responses between model-scale and full-scale building was maintained. The research showed 0.8 to be a reasonable standard value for the inertial coefficient.