The current study presents a simple setup method for making teeth models using a three-axis CNC milling machine. Physical teeth models can be made by several methods: casting, machining, and three-dimensional printing. Since the shape of a teeth model requires five-axis machining, the machining of a teeth model using a three-axis CNC milling machine requires careful setup operations. In this paper a simple datum shape is designed within the work piece of the teeth model. The datum shape is an n-sided prism with regular n-polygon ends and rectangular sides. In the present study a 12-sided prism is used, which easily makes 30 degree rotations for finish machining. The proposed setup approach does not require any special tools for making the teeth model using a three-axis CNC milling machine. A test was run and the results show that the proposed approach is useful for experimental makings with the limited facilities available.