Thresholding in frequency domain is a simple and effective noise reduction technique. Determination of the threshold is critical to the image quality. The optimal threshold minimizing the Mean Square Error (MSE) is chosen adaptively in the wavelet domain; we utilize an equation of the MSE for the soft-thresholded signal and the histogram of wavelet coefficients of the original image and noisy image. The histogram of the original signal is estimated through the deconvolution assuming that the probability density functions (pdfs) of the original signal and the noise are statistically independent. The proposed method is quite general in that it does not assume any prior for the source pdf.