This article presents a new generation of empirical ground motion models for the prediction of response spectral accelerations in soil conditions, specifically developed for the Vrancea intermediate-depth seismic source. The strong ground motion database from which the ground motion prediction model is derived consists of over 800 horizontal components of acceleration recorded from nine Vrancea intermediate-depth seismic events as well as from other seventeen intermediate-depth earthquakes produced in other seismically active regions in the world. Among the main features of the new ground motion model are the prediction of spectral ordinates values (besides the prediction of the peak ground acceleration), the extension of the magnitudes range applicability, the use of consistent metrics (epicentral distance) for this type of seismic source, the extension of the distance range applicability to 300 km, the partition of total standard deviation in intra- and inter-event standard deviations and the use of a national strong ground motion database more than two times larger than in the previous studies. The results suggest that this model is an improvement of the previous generation of ground motion prediction models and can be properly employed in the analysis of the seismic hazard of Romania.