Purpose: The purpose of this study is to report the effect on cold hypersensitivity of hands, feet and low abdomen by Sasang constitutional treatment. For this purpose, the effects of a treatment were measured quantitatively using Digital Infrared Thermographic Imaging (DITI). Methods: It was a case of report, the patient was a 25-year-old female whose chief complaint was cold hypersensitivity of hands and feet and low abdomem. We treated the patient with Sasang constitutional treatment, and the effect of a treatment was evaluated by DITI. Results: After Sasang constitutional treatment, the differences of temperature of hands, feet and low abdomem were decreased on DITI screening, respectively. Conclusions: Sasang constitutional treatment on cold hypersensitivity of hands, feet and low abdomen is effective. Further studies on diagnosis tools of low abdomen cold hypersensitivity are needed.