Objectives : The purpose of this study was to investigate the effects of self-esteem and interpersonal relationship abilities on department satisfaction in the dental hygiene students. Methods : A self-reported questionnaire was filled out by the dental hygiene students in Busan and Ulsan from March to May 2013. Results : Self-esteem had a positive relation with interpersonal relationship abilities(r=0.487, p<0.001) and department satisfaction (r=0.308, p<0.001). Interpersonal relationship had influence on department satisfaction (r=0.347, p<0.001). Multiple regression analysis showed positive relations with aptitude for dental hygienics(p<0.001), satisfaction with school facilities(p<0.001), interpersonal relationship abilities(p<0.001), choice motive for dental hygiene(p<0.05), self-esteem(p<0.05), and gender(p<0.05). Conclusions : To improve the department satisfaction, it is necessary to enhance self-esteem and interpersonal relationship abilities in the dental hygiene students by group counseling and active communication program.