This paper presents the results of an experimental study of wave run-ups on a semi-submersible offshore structure. A series of model tests with a 1:80 scale ratio were carried out in the two-dimensional wave basin of MOERI/KIOST. The experimental model had two columns and one pontoon. The model was fixed and wave elevations were measured at five points per column. Two different draft (operational & survival) conditions and three wave heights were considered under regular wave conditions. First, the nonlinear characteristics of wave run-ups are discussed by using the time series data. Then, the wave heights are compared with numerical results based on the potential flow model. The comparison shows fairly good correlation between the experiments and computations. Finally, wave run-ups under the operational and survival conditions are suggested.