Based on the test on a 1/2.5-scaled model of a two-bay and three-story inner frame composed of reinforced concrete beams and lattice steel reinforced concrete (SRC) irregular section columns under low cyclic reversed loading, the failure process and the features of the frame were observed. The subsequence of plastic hinges of the structure, the load-displacement hysteresis loops and the skeleton curve, load bearing capacity, inter-story drift ratio, ductility, energy dissipation and stiffness degradation were analyzed. The results show that the lattice SRC inner frame is a typical strong column-weak beam structure. The hysteresis loops are spindle-shaped, and the stiffness degradation is insignificant. The elastic-plastic inter-story deformation capacity is high. Compared with the reinforced concrete frame with irregular section columns, the ductility and energy dissipation of the structure are better. The conclusions can be referred to for seismic design of this new kind of structure.