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Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea
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  • Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea
  • Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea
저자명
Lee. Jin Wook,Eo. Hyun Ji,Park. Gwang Hun,Song. Hun Min,Woo. So Hee,Kim. Mi Kyoung,Eom. Jung Hye,Lee. Man Hyo,Lee. Jeong Rak,Koo
간행물명
大韓本草學會誌
권/호정보
2014년|29권 2호|pp.1-6 (6 pages)
발행정보
대한본초학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objectives : Reactive oxygen species (ROS) are involved in a wide spectrum of diseases including chronic inflammation and cancer. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the extracts from the herbal teas such as Lonicera japonica Thunberg (L. japonica), Chrysanthemum morifolium Ramat (C. morifolium), Mentha arvensis L. (M. arvensis), and P.rhizoma. Methods : Anti-oxidant activity was evaluated using DPPH radical scavenging assay and $Fe^{2+}$ chelating assay. And DNA cleavage assay was performed to evaluate an anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell line. Results : L. japonica scavenged DPPH radical by 9.8% at 12.5 ${mu}g/ml$, 24.8% at 25 ${mu}g/ml$, 34.3% at 50 ${mu}g/ml$, 61.1% at 100 ${mu}g/ml$ and 75.8% at 200 ${mu}g/ml$, respectively. In addition, C. morifolium and M. arvensis removed DPPH radical by 15.6% and 10.4% at 12.5 ${mu}g/ml$, 34.8% and 22.8% at 25 ${mu}g/ml$, 66.9% and 43.3% at 50 ${mu}g/ml$, 87.4% and 69.1% at 100 ${mu}g/ml$, and 92.1% and 73.2% at 200 ${mu}g/ml$, respectively. However, P. rhizoma did not affect on DPPH radical scavenging. The $Fe^{2+}$ chelating activity was highest in L. japonica, but lowest in P. rhizoma among the herbal teas. In addition, the extracts from L. japonica, C. morifolium and M. arvensis inhibited oxidative DNA damage via its anti-oxidant activity. In anti-inflammatory effect, the extracts from C. morifolium inhibited NO production. In addition, it suppressed the $NF-{kappa}B$ signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions : Together, this study indicates that L. japonica, M. arvensis and C. morifolium possess the protective effect against the oxidative DNA damage. Furthermore, C. morifolium exerts an anti-inflammatory effect.