Since a typical plate heat exchanger is made up of a huge number of unitary cells, it may be impossible to predict the aero-thermal performance of the full scale heat exchanger through three-dimensional numerical simulation due to the enormous amount of computing resources and time required. In the present study, a simple flow-network model using the friction factor correlation and a thermal-network model based on the effectiveness-number of transfer units (${varepsilon}$-NTU) method has been developed. The complicated flow pattern inside the cross-corrugated heat exchanger has been modeled into flow and thermal networks. Using this model, the heat transfer between neighboring streams can be considered, and the pressure drop and the heat transfer rate of full-scale heat exchanger matrix are calculated. In the calculation, the aero-thermal performance of each unitary cell of the heat exchanger matrix was evaluated using correlations of the Fanning friction factor f and the Nusselt number Nu, which were calculated by unitary-cell CFD model.