Purpose: This study was conducted in order to identify factors that predict suicidal ideation and depression according to gender among Korean adults. Method: From the data base of the fifth Korean National Health and Nutritional Examination Survey(KNHANESV-1, 2010), data on 4,894 adults aged 19~64 were used. Data were analyzed by application of the Rao-Scott Chi-Square test and logistic analysis with SAS 9.2. Results: Overall, 8.5% of men and 18.1% of women had suicidal ideation during the last year; 7.5% of men and 17.0% of women had depression during the last two weeks. Risk factors for suicidal ideation include perceived high stress(OR male 3.649, female 2.941), depression(OR male 10.109, female 6.033), poor cognition of health status(OR male 8.115, female 6.664), low economic status(OR male 1.898), and low educational status(OR female 1.631). Risk factors for depression include perceived high stress(OR male 2.678, female 3.686), suicidal ideation(OR male 9.925, female 6.022), non-employed(OR female 1.525), married(OR female 2.392), and physical discomfort(OR female 1.545). Conclusions: Based on the above mentioned results, risk factors of suicidal ideation and depression differed according to gender. Development of various policies and appropriate intervention programs according to gender, that lessen the risk of suicidal ideation and depression for adults is needed.