In this study, we perform the optimization of trailing arm bush in a vehicle rear suspension to improve the ride and handling performance. A design problem was formulated considering 2 objective functions and 7 constraints related to vehicle ride and handling performance. PIAnO, one of the PIDO (Process Integration and Design Optimization) tool, was used to automate analysis procedures and perform a design optimization. In order to assess relation between performances and design variables, we perform the DOE (Design of Experiments). To find the optimal solution, we used Progressive quadratic response surface method (PQRSM), one of the design optimization techniques equipped in PIAnO. As an optimization result, we got an optimal solution and could improve lateral force steer off-center by 43.0% while decreasing brake compliance at wheel center by 8.1%.