Dongdaemun Fashion District has been successfully positioned as the main hub for fashion product distribution in Korea since 1960 thanks to its unique and successful fashion merchandising system. This system enables the distributors to respond quickly to consumer need and inexpensive price. However, at the present time, Dongdaemun Fashion District has been facing serious challenges from new types of retail stores such as fast fashion brands like ZARA and online shopping malls. To achieve this result, statistical analysis was performed using data from 68 employees of wholesalers in the Dongdaemun Fashion District. They were required to answer questions regarding the marketing system supporting program, amenities like restrooms, and traffic congestion. For the case study, C.I.S, a successful global wholesale system in Italy, was selected. C.I.S has 130 offices offering professional services in the field of trade, legal and tax issues, and insurance. This study suggests cooperation among related wholesalers in order to make an area management plan in the Dongdaemun Fashion District. Also, for the wholesalers to build up product information system and infrastructure for the Global marketing strategy.