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Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice
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  • Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice
  • Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice
저자명
Han. Seungrie,Hong. Soontaek,Mo. Jiwon,Lee. Dongmin,Choi. Eunju,Choi. June-Seek,Sun. Woong,Lee. Hyun Woo,Kim. Hyun
간행물명
Molecules and cells
권/호정보
2014년|37권 1호|pp.24-30 (7 pages)
발행정보
한국분자세포생물학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.