Because of industrial development, industrial facilities are becoming more complex and diversified. Plant industries are focused on productivity improvement, cost reduction, and product uniformity by simplifying production processes using automated control. Furthermore, plant industries require higher pressures and temperatures to improve energy efficiency. For this reason, the valves used in plants are operated under harsh conditions. Globe valves and gate valves are mainly used for high pressure these days. However, these valves have various problems, including low maintainability and high cost, due to structural problems. Therefore, butterfly and ball valve applications are increasing in industrial plants. This paper suggests a quadruple-offset butterfly valve that is applicable to bi-direction use, and the principle design parameters are suggested. The selected design parameters are an eccentric flange center line and shaft centerline(Offset 1), an eccentric seat centerline and disc shaft centerline(Offset 2), the angle between the flange centerline and seat wedge angle(Offset 3), the angle between the vertical direction of the disc shaft centerline and seat centerline(Offset 4), and the seat engagement angle. To analyze the interaction effect of the design parameters, ANOM and ANOVA were performed with an orthogonal array. The parameters were found to have effects in the following order: Offset 2, Offset 1, engagement angle, Offset 3, and Offset 4. The interaction between the parameters was insignificant.