Many studies are being conducted with the aim of reducing the energy consumption in data centers, which are one of the highest consumers of energy. The use of an air-side economizer system that uses external air during intermediate and winter seasons is being considered for reducing the energy consumption of air conditioners. In this study, using the energy simulation, we evaluated the energy performance of a central chilled water cooling system and air-side economizer system in domestic data centers. Further, the cost-effectiveness of the air-side economizer was analyzed through Life-Cycle Cost Analysis. The results showed that with the use of air-side economizer systems, the energy costs increased as the applied filter grade increased; however, unlike existing central chilled water systems, it would break even within 2 years.