In this study, ibuprofen(IBP) degradation by the photochemical ($UV/S_2O{_8}^{2-}$) and sonochemical ($US/S_2O{_8}^{2-}$) processes was examined under various parameters, such as UV ($10{sim}40{pm}5W/L$) and US ($50{sim}90{pm}5W/L$) power density, optimum dosage of persulfate ion ($S_2O{_8}^{2-}$), temperature ($20{sim}60^{circ}C$) and anions effect ($Cl^-$, $HCO_3{^-}$, $CO{_3}^{2-}$). The pseudo-first-order degradation rate constants were in the order of $10^{-1}$ to $10^{-5}min^{-1}$ depending on each processes. The synergistic effect of IBP degradation in $UV/S_2O{_8}^{2-}$ and $US/S_2O{_8}^{2-}$ processes could investigated, due to the generation of $SO_4{^-}$ radical. This result can confirm from the produced $H_2O_2$ and $SO{_4}^{2-}$ concentration in each processes. IBP degradation rate affected by the $S_2O{_8}^{2-}$ dosage, temperature, power and anion existence parameters. In particular, IBP degradation rate increased with the increase of the temperature ($60^{circ}C$) and applied power density (UV:$40{pm}5W/L$, US:$90{pm}5W/L$). On the other hand, anions effect on the IBP degradation was negative, due to the anion play as a the scavenger of radical.