Purpose: The purpose of this study was to investigate the factor affecting adjustment of freshmen nursing students to college life. Method: The data were collected from questionnaires filled out by 265 nursing students six schools from all parts of the country from May 19 to June 4, 2010. Data was analyzed by the SPSS (frequency, ANOVA, and multiple regression analysis) program. Results: A positive correlation was found for college adjustment with psychological well-being, coping and mother attachment. The strongest predictor of college adjustment was an psychological well-being. In addition psychological well-being, coping, and contact frequency for interview with professor accounted for 39.2% of variance in college adjustment. Conclusion: The results of this study suggest that development of psychological well-being and coping in nursing students is important to college adjustment. Further research in improving psychological well-being and coping is warranted.