CD28/T cell receptor ligation activates the NF-${kappa}B$ signaling cascade during CD4 T cell activation. NF-${kappa}B$ activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-${kappa}B$ activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-${kappa}B$ activation pathway and its effect on Th17 cell differentiation.