The resistance of a high speed monohull can be dramatically increased at the high speed range due to the severe stern trim, spray formation and hull bottom pressure irregularity etc. In order to avoid these demerits associated with this resistance increase, various appendages such as the stern wedge, vertical wedge, stern flap, spray strip etc. have been studied. Each of appendage can control the trim angle and/or improve the resistance performance. If these appendages are combined for finding the maximal resistance reduction, there are enormous combination selections. This paper presents the DOE(Design of experiment) using an orthogonal array in order to decrease the model tests finding the optimum appendage combination. And we evaluate that the method introduced in this paper makes the optimal combination of appendages efficient and time-saving by applying to high speed semi-planing monohull. Here, the maximum speed and the least fuel expense are adopted as the decision criteria.